Pdf effective analysis of atorvastatin versus simvastatin in. Consider dose reduction with atorvastatin, lovastatin or simvastatin, given potential for cyp3a4 and pgp mediated interactions. Zocor simvastatin is a good medication to improve your cholesterol. Weekly versus daily dosing of atorvastatin mdedge family. Fish oil epa dietary supplement or prescription vascepa no side effects except burping with dietary supplements, but less effective. Higher with simvastatin 80 mg lower doses in asians 5.
Pdf although there is little information from primary or secondary prevention trials on cholesterollowering medication in diabetic patients, the. Atorvastatin inhibits a ratedetermining enzyme located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol produced. Pdf we directly evaluate the safety and dose efficacy of the 3hydroxy3 methylglutaryl coenzyme a hmgcoa reductase inhibitor. In the secondary analysis, which compared the efficacy of atorvastatin 10 mg with that of simvastatin 10 mg, the mean decrease in ldl cholesterol was significantly greater p atorvastatin 10 mg than for simvastatin 10 mg 37. Dose conversion table for statins benefits english. Lipitor atorvastatin and crestor rosuvastatin are hmgcoa reductase inhibitors statin drugs that lower cholesterol levels in the blood to reduce risk of heart attacks and stroke in.
An overview of cards collaborative atorvastatin diabetes study. If you miss a dose of lipitor, take it as soon as you remember. If you have kidney disease, atorvastatin could be a good choice for you because there is no need to adjust the dosage. Simvastatin zocor, generics 10 mg start with 5 mg in patients with severe renal insufficiency and monitor closely. Both atorvastatin and simvastatin share some possible side effects, including. Chemical, pharmacokinetic and pharmacodynamic properties. Less is more when discussing ldl levels, but not when it comes to cpk levels and the risk of rhabdomyolysis. Scribd is the worlds largest social reading and publishing site. Renal effects of atorvastatin and rosuvastatin in patients. Z comparative study of atorvastatin plus fenofibrate. To evaluate and compare the efficacy and safety of rosuvastatin versus atorvastatin in a highrisk chinese population with hypercholesterolemia.
Weekly dosing has the potential to lower costs and increase convenience while maintaining a similar effect on lipids. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes cards overview 1 a multicenter randomized placebo controlled trial to determine hard outcomes of atorvastatin 10mg vs. Comparative effectiveness of rosuvastatin versus other statins 5 reductions 1 to 4. In my mind, there was little doubt of these facts long before the fda finally acted, which is why this physician, for one, prescribed lipitor for those patients who could obtain it and might benefit by switching to it from simvastatin. Compare atorvastatin vs lovastatin vs pravastatin vs. Interventions patients were randomly assigned to receive a high dose of atorvastatin 80 mgd. Both drugs are used to treat a host of cardiovascular diseases including heart disease and to prevent heart failure. Lipitor and zocor are statins used to treat high blood pressure and heart diseases that can lead to heart attack. Take lipitor each day at any time of day at about the same time each day. Your doctor should start you on a lowfat diet before giving you lipitor. Prescribed for high cholesterol, high cholesterol familial heterozygous. Statins like zocor and lipitor lowering lipids such as cholesterol in the blood, which reduces the risk of heart disease. Lipitor 5mg, 10 mg, 20 mg 40 mg chewable tabletsand. Comparison of the clinical benefit of statins on the basis of randomized controlled endpoint studies.
Atorvastatin is a member of the drug class known as statins, used for lowering cholesterol and thereby reducing cardiovascular disease. Effects on hdl cholesterol were not different between atorvastatin and the other reductase inhibitors except at the 20mg dose when atorvastatin produced greater elevations in hdl cholesterol than simvastatin. Comparison of benefits and risks of rosuvastatin versus. Steven nissens editorial expressed his concerns about increased rates of myopathy in patients on simvastatin. Management of drugdrug interaction with statins joseph saseen, pharmd, bcps, bcacp, cls, fnla professor and vice chair. Lipitor significantly reduced the rate of coronary events either fatal coronary heart disease 46 events in the placebo group vs. At week 16, a greater proportion of atorvastatin treated patients than those treated with simvastatin 46% vs. Mevacor lovastatin can improve cholesterol, but its not as strong as other statin medicines. Lipitor, or generic atorvastatin, is a medication that mostly is used to lower ldl the bad cholesterol.
An overview of ideal a comparison of intensive statin vs. Atorvastatin, cerivastatin withdrawn from clinical use in 2001. There were no significant differences between the treatment groups for allcause mortality. Compare lipitor vs simvastatin comprehensive analysis by.
Atorvastatin lipitor and simvastatin zocor are both statintype drugs that reduce bloodstream cholesterol. You need to have liver tests, muscle problems including rhabdomyolysis, cognitive deficits with statins. Comparative study of atorvastatin plus fenofibrate versus atorvastatin alone for its safety and efficacy in hyperlipidemic patients disha bp, rina n desai, anand is, patel cn department of clinical pharmacy and pharmacology, shri sarvajanik pharmacy college, mehsana, gujarat, india. Despite having similar sounding names and both being statins that are used to treat a build up of bad cholesterol ldl, atorvastatin and simvastatin brand name zocor are different medicines. Highrisk patients ideal trial overview 1 a multicenter prospective randomized openlabel, blinded endpoint trial to determine lipid lowering effects of high dose atorvastatin vs lowmoderate dose. Tricor fenofibrate is used to correct a mixed profile, when someone has not only high ldl, but also high triglycerides blood fat level and low hdl. Of the two, atorvastatin is slightly more effective at reducing your ldl levels. Management of drugdrug interaction with statins joseph saseen, pharmd, bcps, bcacp. Why physicians favored lipitor over simvastatin clinical. An overview of cards collaborative atorvastatin diabetes. Efficacy and safety of rosuvastatin versus atorvastatin in. Highdose atorvastatin vs usualdose simvastatin for. Comparison of benefits and risks of rosuvastatin versus atorvastatin from a metaanalysis of headtohead randomized controlled trials.
Atorvastatin vs simvastatin mean percent change in lipids at 16 weeks 10 7 7. Atorvastatin versus simvastatin tips and tricks from doctors. Main outcome measure occurrence of a major coronary event, defined as coronary death, confirmed nonfatal acute mi. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks. Comparison of the efficacy of rosuvastatin versus atorvastatin, simvastatin, and pravastatin in achieving lipid goals. Lipitor atorvastatin improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease.
Frequently asked questions faqs about lipitor and cholesterol below are some faqs that you may still have after visiting lipitor. An overview of ideal a comparison of intensive statin vs low moderate statin therapy in stable cad patients with a previous mi e. Statin conversion chart % ldl reduction simvastatin zocor atorvastatin lipitor rosuvastatin crestor fluvastatin lescol lovastatin mevacor pravastatin. The first large trial that studied a renal hard outcome as a secondary objective showed that simvastatin combined with ezetimibe had no significant effect on the composite outcome of doubling of serum creatinine.
Efficacy of atorvastatin compared with simvastatin in. A total of 241 drugs are known to interact with simvastatin. Lipitor is a prescription medicine that lowers the ldlc bad cholesterol and triglycerides in your blood. Lovastatin pravastatin simvastatin % ldl reduction. Statine wechselwirkende protease inhibitoren pi empfehlungen.
The proportions of subjects who experienced cv or noncv death were similar for the lipitor 80 mg group and the simvastatin 2040 mg group. Consult product labeling regarding use of this dose. Route onset peak duration atorvastatin atorevastatin. Atorvastatin compared with simvastatinbased therapies in. This 6 week, prospective, multicenter, doubleblind, threearm, parallelgroup, activecontrolled study randomized adult chinese patients lowdensity lipoprotein cholesterol ldlc. On the other hand, simvastatin can affect your kidneys when given at the highest dosage 80 mg per day. Hmgcoareductaseinhibitors pregnancycategoryx indications adjunctive management of primary hypercholesterolemia and mixed dyslipidemia. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Comparative effectiveness of rosuvastatin versus other statins. Atorvastatin 10 mg therapy was substituted for simvastatin 20 mg, 20 mg for 40 mg, 40 mg for simvastatin 40 mg plus resin, and 80 mg for simvastatinfibrateresin therapy.